I32E and V36K double mutation in beta2-sheet abrogates amyloid beta peptide toxicity. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

I32E and V36K double mutation in beta2-sheet abrogates amyloid beta peptide toxicity.

Dataset

identifier:	1803532
description:	epitope description:DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA antigen name:Amyloid beta A4 protein host organism:Oryctolagus cuniculus albino
aggregation:	instance of dataset
availability:	available
primaryPublications:	21117449

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1021116
landingPage:	http://www.iedb.org/assay/1803532

Publication

type:	Literature
publicationVenue:	Indian J Exp Biol
dates:	2010

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Sarada Subramanian Pradeep Kumar Mishra Debashree Bandopadhyay

Data Type

method:	ELISA

Study

name:	I32E and V36K double mutation in beta2-sheet abrogates amyloid beta peptide toxicity.
description:	Double amino acid substitutions at residues I32E and V36K did not affect polyclonal antiserum binding, but significantly reduced fibril formation by thioflavin T assay and abrogated epitope toxicity on human erythrocytes.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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