Carboxyl end-specific monoclonal antibodies to amyloid beta protein (A beta) subtypes (A beta 40 and A beta 42(43)) differentiate A beta in senile plaques and amyloid angiopathy in brains of aged cynomolgus monkeys.

Title:

Dataset

identifier:	1805784
description:	epitope description:DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV antigen name:Amyloid beta A4 protein host organism:Oryctolagus cuniculus antibody name:alpha1280
aggregation:	instance of dataset
availability:	available
primaryPublications:	8848240

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1021113
landingPage:	http://www.iedb.org/assay/1805784

Publication

type:	Literature
publicationVenue:	Neurosci Lett
dates:	1995

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	S Nakamura A Tamaoka N Sawamura S Shoji H Nakayama F Ono I Sakakibara Y Yoshikawa H Mori N Goto

Data Type

method:	immuno staining

Study

name:	Carboxyl end-specific monoclonal antibodies to amyloid beta protein (A beta) subtypes (A beta 40 and A beta 42(43)) differentiate A beta in senile plaques and amyloid angiopathy in brains of aged cynomolgus monkeys.
description:	The epitope sequence is from the reference cited: Roher et al. (1993) Proc Natl Acad Sci U S A 90(22):10836-40 [PMID: 8248178]. The epitope-specific rabbit anti- Aß 1-40 antibody immunostained all types of senile plaques (classical, primitive, and diffuse plaques) in the cerebral cortex of aged monkeys. The antibody stained parenchymal, meningeal arterioles and capillaries in amyloid angiopathy lesions.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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