Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.

Title:

Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.

identifier:	1806262
description:	epitope description:DAEFRHDSGYEVHHQK antigen name:Amyloid beta A4 protein host organism:Mus musculus antibody name:mAb40.1
aggregation:	instance of dataset
availability:	available
primaryPublications:	17068112

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Yona Levites Lisa A Smithson Robert W Price Rachel S Dakin Bin Yuan Michael R Sierks Jungsu Kim Eileen McGowan Dana Kim Reed Terrone L Rosenberry Pritam Das Todd E Golde

method:	immunoprecipitation

name:	Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.
description:	The epitope sequence is from the reference cited: Bard et al. (2004) Proc Natl Acad Sci U S A 100(4):2023-8 [PMID: 12566568]. MAb40.1, specific for the C-terminal region of Aß 1-40, was used as the capture antibody in an ELISA to measure Aß levels and Aß/mAb9 complexes in the plasma of Tg2576 mice treated with epitope-specific mAb9. Mab40.1 was also used as the capture antibody to measure Aß levels in the brains and CSF of mAb9-treated Tg2576 mice. Mice dosed with mAb9 once or every week for 4 wk showed elevated Aß in plasma and CSF, but no significant change in Aß 1-40 levels in RIPA brain extracts.

name:	iedb
homePage:	http://www.iedb.org

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