Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models. |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1021121 |
| landingPage: |
http://www.iedb.org/assay/1806263 |
| type: |
Literature
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| publicationVenue: |
FASEB J
|
| dates: |
2006
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Yona Levites
Lisa A Smithson
Robert W Price
Rachel S Dakin
Bin Yuan
Michael R Sierks
Jungsu Kim
Eileen McGowan
Dana Kim Reed
Terrone L Rosenberry
Pritam Das
Todd E Golde
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| method: |
ELISA
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| name: |
Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.
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| description: |
The epitope sequence is from the reference cited: Bard et al. (2004) Proc Natl Acad Sci U S A 100(4):2023-8 [PMID: 12566568].
MAb 4G8, specific for Aß 17-24, was used as the detecting antibody in a two-site ELISA to measure Aß levels in the plasma of Tg2576 mice treated with epitope-specific mAb9. MAb 4G8 was also used as the detecting antibody to measure Aß levels in the brains and CSF of mAb9-treated Tg2576 mice and plasma and brains of mAb9-treated BRI-Aß42B mice. Mice dosed with mAb9 once or every week for 4 wk showed elevated Aß in plasma and CSF, but no significant change in Aß 1-40 levels in RIPA brain extracts.
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| name: |
iedb
|
| homePage: |
http://www.iedb.org |