Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | High antigen levels do not preclude B-cell tolerance induction to alpha1,3-Gal via mixed chimerism. |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1013796 |
| landingPage: |
http://www.iedb.org/assay/1804622 |
| type: |
Literature
|
| publicationVenue: |
Xenotransplantation
|
| dates: |
2008
|
| study type: | b cell assays |
| subject species: | Oryctolagus cuniculus |
| fullName: |
Fabienne Haspot
Philip D Bardwell
Guiling Zhao
Megan Sykes
|
| method: |
ELISPOT
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| name: |
High antigen levels do not preclude B-cell tolerance induction to alpha1,3-Gal via mixed chimerism.
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| description: |
The ELISA titer of anti-alpha-Gal sera IgM and the number of splenic B cells secreting anti-alpha-Gal IgM in GalT KO mice that had received non-myeloablative conditioning and bone marrow (alpha-Gal+) transplant implantation were not augmented after immunization with rabbit red blood cells (RBC) that are high densitiy alpha-Gal+. This results implies that exposure to high levels of alpha-Gal does not impair alpha-Gal-specific B-cell tolerance after establishment of mixed chimerism in GalT KO recipient mice.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |