Transgenic mouse brain histopathology resembles early Alzheimer's disease. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Transgenic mouse brain histopathology resembles early Alzheimer's disease.

Dataset

identifier:	1804745
description:	epitope description:DAEFRHDSGYEVHHQKL antigen name:Amyloid beta A4 protein host organism:Mus musculus antibody name:4.1
aggregation:	instance of dataset
availability:	available
primaryPublications:	7513982

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1021115
landingPage:	http://www.iedb.org/assay/1804745

Publication

type:	Literature
publicationVenue:	Ann Neurol
dates:	1994

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	L S Higgins D M Holtzman J Rabin W C Mobley B Cordell

Data Type

method:	ELISA

Study

name:	Transgenic mouse brain histopathology resembles early Alzheimer's disease.
description:	The epitope sequence is from the reference cited: Podlisny et al. (1991) Am J Pathol 138(6):1423-35 [PMID: 1905108]. The epitope-specific mAb 4.1 reacted with the epitope and the longer immunizing peptide Aß 1-28 by ELISA. MAb 4.1 reacted with Aß 1-11 only at high concentrations of the peptide.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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