Adjuvants influence the immunoglobin subclass distribution of immune responses in vivo. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Adjuvants influence the immunoglobin subclass distribution of immune responses in vivo.

Dataset

identifier:	1808027
description:	epitope description:fluorescein isothiocyanate host organism:Mus musculus CBA
aggregation:	instance of dataset
availability:	available
primaryPublications:	6424231

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019125
landingPage:	http://www.iedb.org/assay/1808027

Publication

type:	Literature
publicationVenue:	Scand J Immunol
dates:	1984

Dimension

study type:	b cell assays
subject species:

Person

fullName:	L Hadjipetrou-Kourounakis E Mö ller

Data Type

method:	ELISPOT

Study

name:	Adjuvants influence the immunoglobin subclass distribution of immune responses in vivo.
description:	Specific antibody-forming cell responses were measured in mouse spleen cells by using epitope-coupled sheep erythrocytes (SRBC) as indicator cells in the haemolytic plaque assay. Immunization with the combination of FITC-HGG with LPS induced the formation of IgG-plaque forming cells primarily of IgG1 and IgG2b subclasses, while the injection of epitope together with Freund's adjuvants gave a marked increase in IgG antibodies, with a strict preference for IgG1.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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