Functional analysis of a murine monoclonal antibody against the repetitive region of the fibronectin-binding adhesins fibronectin-binding protein A and fibronectin-binding protein B from Staphylococcus aureus.

Title:

Dataset

identifier:	1808061
description:	epitope description:KYEQGGNIVD antigen name:Fibronectin binding protein B, putative host organism:Mus musculus antibody name:15E11
aggregation:	instance of dataset
availability:	available
primaryPublications:	20875085

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1021227
landingPage:	http://www.iedb.org/assay/1808061

Publication

type:	Literature
publicationVenue:	FEBS J
dates:	2010

Dimension

study type:	b cell assays
subject species:	Staphylococcus aureus

Person

fullName:	Giulio Provenza Maria Provenzano Livia Visai Fiona M Burke Joan A Geoghegan Matteo Stravalaci Marco Gobbi Giuliano Mazzini Carla Renata Arciola Timothy J Foster Pietro Speziale

Data Type

method:	ELISA

Study

name:	Functional analysis of a murine monoclonal antibody against the repetitive region of the fibronectin-binding adhesins fibronectin-binding protein A and fibronectin-binding protein B from Staphylococcus aureus.
description:	The epitope sequence was conserved in fibronectin-binding protein A (FnBPA) and fibronectin-binding protein B (FnBPB). The epitope specific mAb recognized fibronectin binding repeat region of FnBPA (FnBRA) and fibronectin binding repeat region of FnBPA (FnBRA) lacking FnBPA-9, FnBPA-10 fragment by ELISA and Western blot. The epitope specific mAb also bound S.aureus bacteria expressing fibronectin-binding protein A (FnBPA), FnBPA-9, FnBPA-10 fragment played an important role during the binding.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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