Diclofenac hypersensitivity: antibody responses to the parent drug and relevant metabolites. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Diclofenac hypersensitivity: antibody responses to the parent drug and relevant metabolites.

Dataset

identifier:	1808156
description:	epitope description:3'-hydroxy-4'-methoxydiclofenac host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	21060839

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1021329
landingPage:	http://www.iedb.org/assay/1808156

Publication

type:	Literature
publicationVenue:	PLoS One
dates:	2010

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Andrea Harrer Roland Lang Robert Grims Michaela Braitsch Thomas Hawranek Werner Aberer Lothar Vogel Walther Schmid Fatima Ferreira Martin Himly

Data Type

method:	ELISA

Study

name:	Diclofenac hypersensitivity: antibody responses to the parent drug and relevant metabolites.
description:	A beta-hexosaminidase release assay was negative using human serum and epitope-HSA conjugate added to RBL-2H3 cells. The basophil activation test was negative measuring CD63 expression after adding epitope HSA conjugate to whole blood. Epitope induced production of sulfidoleukotrienes from PBMCs was negative.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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