Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.

Title:

Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.

identifier:	1806316
description:	epitope description:MVGGVVIA antigen name:Amyloid beta A4 protein host organism:Mus musculus antibody name:mAb9
aggregation:	instance of dataset
availability:	available
primaryPublications:	17068112

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Yona Levites Lisa A Smithson Robert W Price Rachel S Dakin Bin Yuan Michael R Sierks Jungsu Kim Eileen McGowan Dana Kim Reed Terrone L Rosenberry Pritam Das Todd E Golde

method:	immunoprecipitation

name:	Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.
description:	The epitope sequence is from the reference cited: Ghiso et al. (2004) J Biol Chem 279: 45897-45908 [PMID: 15322125]. MAb9, specific for Aß 1-16, was used as the capture antibody in an ELISA to measure total Aß levels and in the plasma, brains and CSF of Tg2576 mice treated with epitope-specific mAb42.2. Mice passively immunized with mAb42.2 showed elevated plasma and CSF Aß, but no significant change in Aß levels in RIPA brain extracts.

name:	iedb
homePage:	http://www.iedb.org

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