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Title: Human natural anti-Gal IgG regulates alternative complement pathway activation on bacterial surfaces.
identifier: 1806470
description:
epitope description:alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-GlcpNAc-yl group
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 1556184
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1008370
landingPage: http://www.iedb.org/assay/1806470
type:
Literature
publicationVenue:
J Clin Invest
dates:
1992
study type: b cell assays
subject species: Serratia marcescens
fullName:
R M Hamadeh
G A Jarvis
U Galili
R E Mandrell
P Zhou
J M Griffiss
method:
biological activity
name:
Human natural anti-Gal IgG regulates alternative complement pathway activation on bacterial surfaces.
description:
Affinity purified epitope-reactive antibodies bound to a serum-sensitive Serratia marcescens isolate and increased complement-dependent lysis of this isolate. However, when anti-epitope antibodies bound to an isolate of Serratia marcescens isolated from blood, the antibodies blocked the complement dependent lysis and made the organism serum-resistant.

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