Mapping of the Neisseria meningitidis NadA cell-binding site: relevance of predicted {alpha}-helices in the NH2-terminal and dimeric coiled-coil regions.

Title:

Mapping of the Neisseria meningitidis NadA cell-binding site: relevance of predicted {alpha}-helices in the NH2-terminal and dimeric coiled-coil regions.

Dataset

identifier:	1807374
description:	epitope description:AYNNGQEINGFKA host organism:Oryctolagus cuniculus New Zealand White
aggregation:	instance of dataset
availability:	available
primaryPublications:	20971901

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1021164
landingPage:	http://www.iedb.org/assay/1807374

Publication

type:	Literature
publicationVenue:	J Bacteriol
dates:	2011

Dimension

study type:	b cell assays
subject species:	Neisseria meningitidis

Person

fullName:	Regina Tavano Barbara Capecchi Paolo Montanari Susanna Franzoso Oriano Marin Maryta Sztukowska Paola Cecchini Daniela Segat Maria Scarselli Beatrice Aricò Emanuele Papini

Data Type

method:	biological activity

Study

name:	Mapping of the Neisseria meningitidis NadA cell-binding site: relevance of predicted {alpha}-helices in the NH2-terminal and dimeric coiled-coil regions.
description:	Rabbit antisera/Fab fragment to the epitope partially inhibited NadA-expressing E.coli adhesion to Chang conjunctiva cells. The antibody/Fab fragment also bound to NadA expressed on the surface of E.coli cells by ELISA at similar level. The antibody recognized NadA expressed on the surface of E.coli cells by FACS.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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