Identification and characterization of broadly neutralizing human monoclonal antibodies directed against the E2 envelope glycoprotein of hepatitis C virus.

Title:

Identification and characterization of broadly neutralizing human monoclonal antibodies directed against the E2 envelope glycoprotein of hepatitis C virus.

Dataset

identifier:	1810747
description:	epitope description:QLINTNGSWHIN antigen name:Genome polyprotein host organism:Mus musculus HuMAb (Medarex) antibody name:HCV1, 95-2
aggregation:	instance of dataset
availability:	available
primaryPublications:	19759151

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017751
landingPage:	http://www.iedb.org/assay/1810747

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2009

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus (isolate H77)

Person

fullName:	Teresa J Broering Kerry A Garrity Naomi K Boatright Susan E Sloan Frantisek Sandor William D Thomas Jr Gyongyi Szabo Robert W Finberg Donna M Ambrosino Gregory J Babcock

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	Identification and characterization of broadly neutralizing human monoclonal antibodies directed against the E2 envelope glycoprotein of hepatitis C virus.
description:	The epitope-specific mAbs bound the epitope, the KD for 95-2 was 1.9 nM, and the KD for HCV1 was 3.8 nM.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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