Lytic anti-alpha-galactosyl antibodies from patients with chronic Chagas' disease recognize novel O-linked oligosaccharides on mucin-like glycosyl-phosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi.

Title:

Dataset

identifier:	1811747
description:	epitope description:alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-GlcpNAc-yl group antigen name:Mucin TcMUCII, putative (UniProt:K4DVA4) host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	7818483

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019252
landingPage:	http://www.iedb.org/assay/1811747

Publication

type:	Literature
publicationVenue:	Biochem J
dates:	1994

Dimension

study type:	b cell assays
subject species:	Trypanosoma cruzi G

Person

fullName:	I C Almeida M A Ferguson S Schenkman L R Travassos

Data Type

method:	chromatography

Study

name:	Lytic anti-alpha-galactosyl antibodies from patients with chronic Chagas' disease recognize novel O-linked oligosaccharides on mucin-like glycosyl-phosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi.
description:	The source molecules are mucin-like glycosyl-phosphatidylinositol (GPI)-anchored molecules bearing oligosaccharide chains O-glycosidically linked mainly to Thr residues in the peptide backbone via N-acetylglucosaminyl units. The anti-alpha-Gal antibody preparation from Chagasic patient is found to react with the epitope (in the oxidized form) from a mixture of galactose-oxidase-labelled oligosaccharides obtained from T. cruzi mucin-like glycoproteins.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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