STD-NMR used to elucidate the fine binding specificity of pathogenic anti-ganglioside antibodies directly in patient serum.

Title:

STD-NMR used to elucidate the fine binding specificity of pathogenic anti-ganglioside antibodies directly in patient serum.

identifier:	1811622
description:	epitope description:beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	19105626

study type:	b cell assays
subject species:	Homo sapiens

fullName:	R Scott Houliston Bart C Jacobs Anne P Tio-Gillen Jan J Verschuuren Nam H Khieu Michel Gilbert Harold C Jarrell

method:	nuclear magnetic resonance (NMR)

name:	STD-NMR used to elucidate the fine binding specificity of pathogenic anti-ganglioside antibodies directly in patient serum.
description:	One patient had an IgM paraprotein with λ light chain and the other patient had an IgM paraprotein with κ light chain. NMR spectroscopy studies show the antibodies contact the epitope (oligo-GM1) in the terminal ßGal and NeuAc residues.

name:	iedb
homePage:	http://www.iedb.org

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