Hepatitis C virus with a naturally occurring single amino-acid substitution in the E2 envelope protein escapes neutralization by naturally-induced and vaccine-induced antibodies.

Title:

Hepatitis C virus with a naturally occurring single amino-acid substitution in the E2 envelope protein escapes neutralization by naturally-induced and vaccine-induced antibodies.

Dataset

identifier:	1811952
description:	epitope description:QLINTNGSWHINSTA antigen name:Genome polyprotein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	20433800

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019762
landingPage:	http://www.iedb.org/assay/1811952

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	2010

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus (isolate H77)

Person

fullName:	Hongying Duan Evi Struble Lilin Zhong Kathleen Mihalik Marian Major Pei Zhang Stephen Feinstone Dino Feigelstock

Data Type

method:	biological activity

Study

name:	Hepatitis C virus with a naturally occurring single amino-acid substitution in the E2 envelope protein escapes neutralization by naturally-induced and vaccine-induced antibodies.
description:	Epitope affinity-purified IgG was able to neutralize HCV.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.

Related Publications

Feedback?