Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.

Title:

Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.

identifier:	1813332
description:	epitope description:T41, Y45, P46, Q47, F72, N73, P74, H75, F76, E77, N107, A133, S136, R138 antigen name:Neuropilin-2 host organism:Homo sapiens antibody name:anti-pan Nrp^A
aggregation:	instance of dataset
availability:	available
primaryPublications:	17989695

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Brent A Appleton Ping Wu Janice Maloney JianPing Yin Wei-Ching Liang Scott Stawicki Kyle Mortara Krista K Bowman J Michael Elliott William Desmarais J Fernando Bazan Anil Bagri Marc Tessier-Lavigne Alexander W Koch Yan Wu Ryan J Watts Christian Wiesmann

method:	surface plasmon resonance (SPR)

name:	Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.
description:	The epitope residues are calculated from [PDB: 2QQL, 2QQK] at 4 Å distance and represent a joined epitope, since it is slightly different in these structures: [PDB: 2QQL] epitope misses R138 residues, while [PDB: 2QQK] epitope misses Y45 and F72 residues. The epitope specific anti-pan Nrp^A Fab binds to Nrp1 domains a1a2b1b2.

name:	iedb
homePage:	http://www.iedb.org

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