Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1813778 |
| description: |
epitope description:C: L328, G329, W330, K331, W332, Y390, Y391, V392, G393, R394, E399, L401; F: Y350, L351, T357, T360, L364
antigen name:Transforming growth factor beta-3
host organism:Homo sapiens
antibody name:GC-1008
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
19073914 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1018813 |
| landingPage: |
http://www.iedb.org/assay/1813778 |
| type: |
Literature
|
| publicationVenue: |
Proc Natl Acad Sci U S A
|
| dates: |
2008
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Christian Grü
tter
Trevor Wilkinson
Richard Turner
Sadhana Podichetty
Donna Finch
Matthew McCourt
Scott Loning
Lutz Jermutus
Markus G Grü
|
| method: |
biological activity
|
| name: |
A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions.
|
| description: |
Epitope specific GC-1008 inhibited the activity of TGF-ß3 in the mink lung epithelial cell (MLEC) proliferation assay, with an IC50 value of 7 nM. GC-1008 was tested for neutralization of TGF-ß3, resulting in restoration of cell proliferation.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
