Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1019864 |
| landingPage: |
http://www.iedb.org/assay/1814117 |
| type: |
Literature
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| publicationVenue: |
J Exp Med
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| dates: |
1972
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| study type: | b cell assays |
| subject species: |
| fullName: |
D P Osborne Jr
D H Katz
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| method: |
radio immuno assay (RIA)
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| name: |
The allogeneic effect in inbred mice. I. Experimental conditions for the enhancement of hapten-specific secondary antibody responses by the graft-versus-host reaction.
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| description: |
Serum anti-DNP antibody levels were determined by a modified Farr technique using DNP-tritiated thymidine-amino-N-caproic acid. Mice immunized with DNP-KLH and boosted two weeks later with DNP-KLH or DNP-BGG produced DNP-specific antibodies. This was not true of BALB/c mice immunized with DNP-carrier. Adoptive transfer of splenic lymphoid cells from non-immunized mice enhanced this response by way of the allogeneic effect related to graft-versus-host reaction. Route of administration, number of transferred cells and interval of secondary transfer all were found to be pertinent factors in the magnitude of response.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
