Identification of a novel linear epitope on EspA from enterohemorrhagic E. coli using a neutralizing and protective monoclonal antibody.

Title:

Identification of a novel linear epitope on EspA from enterohemorrhagic E. coli using a neutralizing and protective monoclonal antibody.

identifier:	1816205
description:	epitope description:KAKLPQEVIDYINDPRNDITV antigen name:Translocator EspA host organism:Mus musculus BALB/c antibody name:1H10
aggregation:	instance of dataset
availability:	available
primaryPublications:	21075691

study type:	b cell assays
subject species:	Escherichia coli

fullName:	Shu Yu Jiang Gu Hai-guang Wang Qing-xu Wang Ping Luo Chao Wu Wei-jun Zhang Gang Guo Wen-de Tong Quan-ming Zou Xu-hu Mao

method:	biological activity

name:	Identification of a novel linear epitope on EspA from enterohemorrhagic E. coli using a neutralizing and protective monoclonal antibody.
description:	The epitope-specific mAb neutralized E. coli EDL933 and inhibited infection of HeLa cells in vitro as shown by immunofluorescence microscopy. Mice challenged in vivo with E. coli EDL933 pre-incubated with the epitope-specific mAb were protected and showed longer survivals and reduced bacterial shedding.

name:	iedb
homePage:	http://www.iedb.org

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