A somatically mutated human antiganglioside IgM antibody that induces experimental neuropathy in mice is encoded by the variable region heavy chain gene, V1-18.

Title:

A somatically mutated human antiganglioside IgM antibody that induces experimental neuropathy in mice is encoded by the variable region heavy chain gene, V1-18.

Dataset

identifier:	1816964
description:	epitope description:alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine host organism:Homo sapiens antibody name:Ha1
aggregation:	instance of dataset
availability:	available
primaryPublications:	8636426

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1018082
landingPage:	http://www.iedb.org/assay/1816964

Publication

type:	Literature
publicationVenue:	J Clin Invest
dates:	1996

Dimension

study type:	b cell assays
subject species:

Person

fullName:	H J Willison G M O'Hanlon G Paterson J Veitch G Wilson M Roberts A Vincent

Data Type

method:	western blot

Study

name:	A somatically mutated human antiganglioside IgM antibody that induces experimental neuropathy in mice is encoded by the variable region heavy chain gene, V1-18.
description:	The mAb also stained a wide array of structures in the rodent PNS, including dorsal root ganglia, peripheral nerve axonal profiles, compact myelin, nodes of Ranvier, motor end plates, and muscle spindles.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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