Cross-neutralization potential of native human papillomavirus N-terminal L2 epitopes. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Cross-neutralization potential of native human papillomavirus N-terminal L2 epitopes.

Dataset

identifier:	1819755
description:	epitope description:GGLGIGTGSGTGGRTGYIPL antigen name:Minor capsid protein L2 host organism:Oryctolagus cuniculus antibody name:anti-P56/75 #1
aggregation:	instance of dataset
availability:	available
primaryPublications:	21346798

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1021655
landingPage:	http://www.iedb.org/assay/1819755

Publication

type:	Literature
publicationVenue:	PLoS One
dates:	2011

Dimension

study type:	b cell assays
subject species:	Human papillomavirus type 16

Person

fullName:	Michael J Conway Linda Cruz Samina Alam Neil David Christensen Craig Meyers

Data Type

method:	biological activity

Study

name:	Cross-neutralization potential of native human papillomavirus N-terminal L2 epitopes.
description:	The epitope sequence was provided in cited reference Kondo et al. Virol 2007 358:266-272 [PMID: 17010405]. The anti-sera neutralized HPV 16 positive cell lines at 20-days, but not at 10 days. While this anti-sera cross-reacted with HPV 31 and HPV 18 types, it did not with HPV 45. Western blot analysis revealed that a T66S substitution in the HPV 45 sequence was sufficient to alter the immunoreactivity.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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