Structure of IL-17A in complex with a potent, fully human neutralizing antibody. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Structure of IL-17A in complex with a potent, fully human neutralizing antibody.

Dataset

identifier:	1818221
description:	epitope description:A: S63, S64, D65, Y66, R69; B: L97, Y108, H109, M110, N111, P149, I150 antigen name:Interleukin-17A host organism:Homo sapiens antibody name:CAT-2200
aggregation:	instance of dataset
availability:	available
primaryPublications:	19835883

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017847
landingPage:	http://www.iedb.org/assay/1818221

Publication

type:	Literature
publicationVenue:	J Mol Biol
dates:	2009

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Stefan Gerhardt W Mark Abbott David Hargreaves Richard A Pauptit Rick A Davies Maurice R C Needham Caroline Langham Wendy Barker Azad Aziz Melanie J Snow Sarah Dawson Fraser Welsh Trevor Wilkinson Tris Vaugan Gerald Beste Sarah Bishop Bojana Popovic Gareth Rees Matthew Sleeman Steven J Tuske Stephen J Coales Yoshitomo Hamuro Caroline Russell

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	Structure of IL-17A in complex with a potent, fully human neutralizing antibody.
description:	The epitope specific CAT-2200 Fab bound to the IL-17A homodimer with an affinity of 2.1 nM compared to KD = 13.5 nM for the parent antibody TINA12. The improved binding was mostly due to a decrease in off-rate.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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