Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopes. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopes.

Dataset

identifier:	1818780
description:	epitope description:alpha-D-galactosyl-(1->3)-D-galactosyl group host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	7504304

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1020679
landingPage:	http://www.iedb.org/assay/1818780

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	1993

Dimension

study type:	b cell assays
subject species:	Sus scrofa

Person

fullName:	M S Sandrin H A Vaughan P L Dabkowski I F McKenzie

Data Type

method:	antigen inhibition

Study

name:	Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopes.
description:	The epitope inhibited the binding of human sera to pig RBCs in a hemagglutination assay. The minimal structure of the epitope was determined by inhibition studies with several different carbohydrates. Human sera reaction with alpha-D-Gal, GalN, Methyl-alpha-Gal, Melibiose, and stachyose, indicating that Gal(alpha1-3)Gal is the minimal structure recognized by human sera.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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