Posttranslationally modified peptides efficiently mimicking neoantigens: a challenge for theragnostics of autoimmune diseases.

Title:

Posttranslationally modified peptides efficiently mimicking neoantigens: a challenge for theragnostics of autoimmune diseases.

identifier:	1819206
description:	epitope description:D-glucosyl group host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	20564034

study type:	b cell assays
subject species:

fullName:	Francesca Nuti Elisa Peroni Feliciana Real-Ferná ndez M Angeles Bonache Alexandra Le Chevalier-Isaad Mario Chelli Nadè ge Lubin-Germain Jacques Uziel Paolo Rovero Francesco Lolli Anna Maria Papini

method:	ELISA

name:	Posttranslationally modified peptides efficiently mimicking neoantigens: a challenge for theragnostics of autoimmune diseases.
description:	Serum IgG from MS patients reacted better with the peptide glucosylated (epitope) at position 7 than serum IgG from healthy controls. The unglycosylated peptide or peptide with the following glycosyl moieties at Asn7 did not bind serum IgG or detect an increase in binding in MS patients' sera: galactose, mannose, N-acetylneuraminic acid and ribose. The peptide with a Asn7Gln, but not Asn7Phe or Asn7Gly substitution, and modification with the epitope at that position also bound to MS patients' sera IgG.

name:	iedb
homePage:	http://www.iedb.org

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