Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope.

Title:

Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope.

identifier:	1819212
description:	epitope description:VVHFFKNIVTPRT antigen name:Myelin basic protein host organism:Mus musculus antibody name:QD9
aggregation:	instance of dataset
availability:	available
primaryPublications:	21314187

study type:	b cell assays
subject species:	Bos taurus

fullName:	Natalie K Cygan Johanna C Scheinost Terry D Butters Paul Wentworth Jr

method:	flow cytometry

name:	Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope.
description:	The epitope-specific mAb recognized the immunodominant epitope on MBP incorporated into large unilamellar vesicles. Inclusion of cholesterol 5,6-secosterols, atheronal-A or atheronal-B, increased the level of mAb binding in a concentration-dependent manner. Oxysterol atheronal analogues did not have a similar effect.

name:	iedb
homePage:	http://www.iedb.org

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