Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1021040 |
| landingPage: |
http://www.iedb.org/assay/1819998 |
| type: |
Literature
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| publicationVenue: |
Eur J Immunol
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| dates: |
1981
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| study type: | b cell assays |
| subject species: |
| fullName: |
K Bottomly
C A Janeway Jr
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| method: |
biological activity
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| name: |
Selected populations of alloreactive T cells contain helper T cells but lack ThId, an antigen-specific helper T cell required for dominant production of the T15 idiotype.
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| description: |
The anti-epitope antibody response was measured by the plaque-forming cell (PFC) assay. Similar responses were observed when the epitope was conjugated to OVA or KLH. Alloreactive T cell populations supported anti-epitope Ab responses, but did not selectively activate B cells capable of producing the T15 idiotype that normally dominates such responses, suggesting that ThId cells have recognition structures for antigen and for self idiotype, but lack recognition structures for MHC-encoded antigens.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
