Use of molecular modeling and site-directed mutagenesis to define the structural basis for the immune response to carbohydrate xenoantigens.

Title:

Use of molecular modeling and site-directed mutagenesis to define the structural basis for the immune response to carbohydrate xenoantigens.

identifier:	1821285
description:	epitope description:alpha-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	17352819

study type:	b cell assays
subject species:	Sus scrofa

fullName:	Mary Kearns-Jonker Natasha Barteneva Robert Mencel Namath Hussain Irina Shulkin Alan Xu Margaret Yew Donald V Cramer

method:	ELISA

name:	Use of molecular modeling and site-directed mutagenesis to define the structural basis for the immune response to carbohydrate xenoantigens.
description:	The epitope structure was previously described in McKane et al., Transplantation:66(626) 1998 [PMID:9753344]. The single chain Abs inhibited binding of human sera to the epitope. Mutation of residues 50 and 54 in the Abs increased inhibition.

name:	iedb
homePage:	http://www.iedb.org

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