HPA-1a phenotype-genotype discrepancy reveals a naturally occurring Arg93Gln substitution in the platelet beta 3 integrin that disrupts the HPA-1a epitope.

Title:

HPA-1a phenotype-genotype discrepancy reveals a naturally occurring Arg93Gln substitution in the platelet beta 3 integrin that disrupts the HPA-1a epitope.

Dataset

identifier:	1822565
description:	epitope description:L48 antigen name:Immunoglobulin host organism:Homo sapiens antibody name:CAMTRAN-007
aggregation:	instance of dataset
availability:	available
primaryPublications:	11861302

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1020361
landingPage:	http://www.iedb.org/assay/1822565

Publication

type:	Literature
publicationVenue:	Blood
dates:	2002

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Nicholas A Watkins Elisabeth Schaffner-Reckinger David L Allen Graham J Howkins Nicolaas H C Brons Graham A Smith Paul Metcalfe Michael F Murphy Nelly Kieffer Willem H Ouwehand

Data Type

method:	flow cytometry

Study

name:	HPA-1a phenotype-genotype discrepancy reveals a naturally occurring Arg93Gln substitution in the platelet beta 3 integrin that disrupts the HPA-1a epitope.
description:	The epitope of the mAb was deduced by loss of bindings to platelets expressing ß3 integrin with a mutation at the epitopic residue (L33P).

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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