Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1822585 |
| description: |
epitope description:V1462, C1463, S1464, L1465, Q1466, N1468, W1497, K1498, Y1499, F1500, S1501, D1502, H1504, D1506, A1707, S1708, L1709, G1710, N1713, I1714, P1715, K1717
antigen name:Neurogenic locus notch homolog protein 1
host organism:Homo sapiens
antibody name:anti-NRR1
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
20393564 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1019695 |
| landingPage: |
http://www.iedb.org/assay/1822585 |
| type: |
Literature
|
| publicationVenue: |
Nature
|
| dates: |
2010
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Yan Wu
Carol Cain-Hom
Lisa Choy
Thijs J Hagenbeek
Gladys P de Leon
Yongmei Chen
David Finkle
Rayna Venook
Xiumin Wu
John Ridgway
Dorreyah Schahin-Reed
Graham J Dow
Amy Shelton
Scott Stawicki
Ryan J Watts
Jeff Zhang
Robert Choy
Peter Howard
Lisa Kadyk
Minhong Yan
Jiping Zha
Christopher A Callahan
Sarah G Hymowitz
Christian W Siebel
|
| method: |
surface plasmon resonance (SPR)
|
| name: |
Therapeutic antibody targeting of individual Notch receptors.
|
| description: |
The epitope residues are calculated from the PDB structure as the antigen residues at 4 Å
distance from the antibody.
Epitope-specific anti-NRR1 Fab bound to human or mouse NRR1 with high affinity as shown by surface plasmon spectroscopy and ELISA. Anti-NRR1 did not bind to NRR2, NRR3 or NRR4.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
