A naturally occurring LeuVal mutation in beta3-integrin impairs the HPA-1a epitope: the third allele of HPA-1.

Title:

A naturally occurring LeuVal mutation in beta3-integrin impairs the HPA-1a epitope: the third allele of HPA-1.

identifier:	1822725
description:	epitope description:L59 antigen name:Integrin beta-3 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	16686847

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Sentot Santoso Hartmut Kroll Cornelia L Andrei-Selmer Ines Socher Angela Rankin Evelyne Kretzschmar Nicholas A Watkins Willem H Ouwehand

method:	immunoprecipitation

name:	A naturally occurring LeuVal mutation in beta3-integrin impairs the HPA-1a epitope: the third allele of HPA-1.
description:	The epitope sequence is found in Fitzgerald LA et al. J Biol Chem. 1987 Mar 25 262(9):3936-9 [PMID:3494014]. The human antibody bound to native beta-3 with Leu in position 33, but not to a variant with Val in that position. The epitope was identified based on this binding.

name:	iedb
homePage:	http://www.iedb.org

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