Schistosoma mansoni infection in humans and primates induces cytolytic antibodies to surface Le(x) determinants on myeloid cells.

Title:

Schistosoma mansoni infection in humans and primates induces cytolytic antibodies to surface Le(x) determinants on myeloid cells.

identifier:	1823668
description:	epitope description:alpha-L-Fucp-(1->3)-[beta-D-Galp-(1->4)]-beta-D-GlcpNAc antigen name:glycoprotein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	8617346

study type:	b cell assays
subject species:	Schistosoma mansoni

fullName:	A K Nyame J B Pilcher V C Tsang R D Cummings

method:	ELISA

name:	Schistosoma mansoni infection in humans and primates induces cytolytic antibodies to surface Le(x) determinants on myeloid cells.
description:	The Lewis x antigen (Lex beta-Gal-1-4-[alpha-Fuc-1-3]-beta-GlcNAc1-R), which is present on the surfaces of human cells, is also synthesized by the human helminthic parasite Schistosoma mansoni. The involvement in immune recognition in this reference is deduced. The infected human sera reacted with the epitope-containing pentasaccharide. No recognition is found by uninfected sera. The fucose involvement in the reactivity is demonstrated since antibodies failed to bind to LNnT-BSA, that lacks the fucose linked a1,3 to GlcNAc found in LNFPIII.

name:	iedb
homePage:	http://www.iedb.org

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