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Title: Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease.
identifier: 1833395
description:
epitope description:KGAIIGLMVGGVV
antigen name:Amyloid beta A4 protein
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 21490226
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1021985
landingPage: http://www.iedb.org/assay/1833395
type:
Literature
publicationVenue:
J Neurosci
dates:
2011
study type: b cell assays
subject species: Mus musculus
fullName:
Richard Dodel
Karthikeyan Balakrishnan
Kathy Keyvani
Oliver Deuster
Frauke Neff
Luminita-Cornelia Andrei-Selmer
Stephan Rö
skam
Carsten Stü
er
Yousef Al-Abed
Carmen Noelker
Monika Balzer-Geldsetzer
Wolfgang Oertel
Yansheng Du
Michael Bacher
method:
in vivo assay
name:
Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease.
description:
Adoptive transfer of epitope-specific autoantibodies isolated from healthy subjects significantly suppressed plaque number and reduced plaque area in 4-month old but not 13-month old APP TgCRND8 mice.

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