Crystal structure of an anti-interleukin-2 monoclonal antibody Fab complexed with an antigenic nonapeptide.

Title:

Crystal structure of an anti-interleukin-2 monoclonal antibody Fab complexed with an antigenic nonapeptide.

identifier:	1828552
description:	epitope description:KPLEEVLNL + METH(L9) antigen name:Interleukin-2 host organism:Mus musculus antibody name:LNKB-2
aggregation:	instance of dataset
availability:	available
primaryPublications:	11468348

study type:	b cell assays
subject species:	Homo sapiens

fullName:	P V Afonin A V Fokin I N Tsygannik I Y Mikhailova L V Onoprienko I I Mikhaleva V T Ivanov T Y Mareeva V A Nesmeyanov N Li W A Pangborn W L Duax V Z Pletnev

method:	ELISA

name:	Crystal structure of an anti-interleukin-2 monoclonal antibody Fab complexed with an antigenic nonapeptide.
description:	The epitope is acetylated at the N-terminus and O-methylated at the C-terminus. The affinity constant of LNKB-2 binding to the epitope was estimated on the basis of competitive inhibition of LNKB-2 binding to IL-2 by the epitope. The affinity of binding to the longer peptide IL-2 (60-72) was slight greater (KA = 1.2 x 10⁸), as determined by a noncompetitive enzyme immunoassay.

name:	iedb
homePage:	http://www.iedb.org

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