Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease.

Title:

Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease.

Dataset

identifier:	1833400
description:	epitope description:KGAIIGLMVGGVV antigen name:Amyloid beta A4 protein host organism:Homo sapiens antibody name:NAbs-Aß
aggregation:	instance of dataset
availability:	available
primaryPublications:	21490226

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1021985
landingPage:	http://www.iedb.org/assay/1833400

Publication

type:	Literature
publicationVenue:	J Neurosci
dates:	2011

Dimension

study type:	b cell assays
subject species:	Mus musculus

Person

fullName:	Richard Dodel Karthikeyan Balakrishnan Kathy Keyvani Oliver Deuster Frauke Neff Luminita-Cornelia Andrei-Selmer Stephan Rö skam Carsten Stü er Yousef Al-Abed Carmen Noelker Monika Balzer-Geldsetzer Wolfgang Oertel Yansheng Du Michael Bacher

Data Type

method:	ELISA

Study

name:	Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease.
description:	Naturally occurring epitope-specific autoantibodies isolated from healthy subjects reacted with peptide fragment Aß1-40 containing the epitope in a dose-dependent manner. The epitope-specific Ab preferentially recognized dimers and trimers and, to a lesser extent, monomeric forms of Aß1-40.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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