Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.

Dataset

identifier:	1833688
description:	epitope description:TPCVPAECFDLLVRHCVACGLLRTPR antigen name:Tumor necrosis factor receptor superfamily member 13C host organism:Homo sapiens antibody name:CB2
aggregation:	instance of dataset
availability:	available
primaryPublications:	16840730

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1018827
landingPage:	http://www.iedb.org/assay/1833688

Publication

type:	Literature
publicationVenue:	Blood
dates:	2006

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Chingwei V Lee Sarah G Hymowitz Heidi J Wallweber Nathaniel C Gordon Karen L Billeci Siao-Ping Tsai Deanne M Compaan Jianping Yin Qian Gong Robert F Kelley Laura E DeForge Flavius Martin Melissa A Starovasnik Germaine Fuh

Data Type

method:	biological activity

Study

name:	Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.
description:	The epitope-specific CB2 mAb competed with BAFF for binding to mBR3 expressed on BHK cells (IC50 = 65 nM for IgG protein), essentially neutralizing receptor function. In vivo treatment with CB2 mAb reduced blood and spleen B cell numbers in BALB/C mice, indicating CB2 reduced B cell proliferation.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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