Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1021990 |
| landingPage: |
http://www.iedb.org/assay/1831223 |
| type: |
Literature
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| publicationVenue: |
J Alzheimers Dis
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| dates: |
2011
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| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Ying Liu
Michael K Lee
Maria M James
Donald L Price
David R Borchelt
Juan C Troncoso
Esther S Oh
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| method: |
in vivo assay
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| name: |
Passive (amyloid-beta) immunotherapy attenuates monoaminergic axonal degeneration in the AbetaPPswe/PS1dE9 mice.
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| description: |
Injections of monoclonal antibody (mAb) 7B6 into mice (6 to 9 months of age) resulted in a modest reduction of Abeta load in the brains of AbetaPPswe/PS1dE9 mice. In addition, 7B6 treated AbetaPPswe/PS1dE9 mice had significantly higher densities of MAergic axons in both cortex and in hippocampus as compared to untreated mutant mice. 7B6 treatment resulted in significant reduction in the insolule fraction of both A beta 40 and A beta 42. 7B6 treated mice showed almost 2-fold greater densities of serotonergic (5-HT) axons in the cortex compared to saline treated mice. Similar findings were observed in the catecholaminergic (TH) axons.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
