A cyclic undecamer peptide mimics a turn in folded Alzheimer amyloid beta and elicits antibodies against oligomeric and fibrillar amyloid and plaques.

Title:

A cyclic undecamer peptide mimics a turn in folded Alzheimer amyloid beta and elicits antibodies against oligomeric and fibrillar amyloid and plaques.

Dataset

identifier:	1831665
description:	epitope description:EDVGSNK antigen name:Amyloid beta A4 protein host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	21526148

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1021989
landingPage:	http://www.iedb.org/assay/1831665

Publication

type:	Literature
publicationVenue:	PLoS One
dates:	2011

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Peter Hoogerhout Willem Kamphuis Humphrey F Brugghe Jacqueline A Sluijs Hans A M Timmermans Janny Westdijk Gijsbert Zomer Claire J P Boog Elly M Hol Germie P J M van den Dobbelsteen

Data Type

method:	ELISA

Study

name:	A cyclic undecamer peptide mimics a turn in folded Alzheimer amyloid beta and elicits antibodies against oligomeric and fibrillar amyloid and plaques.
description:	Antisera to the cyclic epitope were strongly cross-reactive with oligomeric or fibrillar Ab(1–42) in ELISA. Five sera showed titers >2000, whereas one serum showed no response (titer<100). The cyclization of the epitope was essential to produce a functional immunogen.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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