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Title: Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes.
identifier: 1831847
description:
epitope description:E445, D614, K615
antigen name:Exotoxin A
host organism:Mus musculus
antibody name:MAb 73, 52, 69
aggregation:
instance of dataset
availability:
available
primaryPublications: 21436054
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1021612
landingPage: http://www.iedb.org/assay/1831847
type:
Literature
publicationVenue:
Proc Natl Acad Sci U S A
dates:
2011
study type: b cell assays
subject species: Pseudomonas aeruginosa
fullName:
Masanori Onda
Richard Beers
Laiman Xiang
Byungkook Lee
John E Weldon
Robert J Kreitman
Ira Pastan
method:
ELISA
name:
Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes.
description:
The epitope was deduced.
The epitope was deduced by loss of binding when Pseudomonas exotoxin A (PE38) molecule was mutated at the epitopic residues. Adjacent mutations D589A or K590A abolished binding of all three mAbs.

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