Epitope fine specificity of human anti-HLA-A2 antibodies. Identification of four epitopes including a haptenlike epitope on HLA-A2 at lysine 127.

Title:

Epitope fine specificity of human anti-HLA-A2 antibodies. Identification of four epitopes including a haptenlike epitope on HLA-A2 at lysine 127.

identifier:	1834336
description:	epitope description:K151 antigen name:HLA class I histocompatibility antigen, A-2 alpha chain host organism:Homo sapiens antibody name:DOUV, L.C.
aggregation:	instance of dataset
availability:	available
primaryPublications:	7503972

study type:	b cell assays
subject species:	Homo sapiens

fullName:	L D De Vito B P Mason E Jankowska-Gan K T Hogan J W Guo C T Lutz H W Sollinger W J Burlingham

method:	antigen inhibition

name:	Epitope fine specificity of human anti-HLA-A2 antibodies. Identification of four epitopes including a haptenlike epitope on HLA-A2 at lysine 127.
description:	HLA-A2 inhibited binding of the epitope-specific purified Abs to rA2/Q10^b. The residue comprising the epitope of the Abs was identified based on loss of binding to mutated HLA-A2 proteins. Although the majority of the binding involved λ Abs, κ Abs also showed significant binding.

name:	iedb
homePage:	http://www.iedb.org

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