Characterization of the murine Th2 response to immunization with liposomal M2e influenza vaccine.

Title:

Characterization of the murine Th2 response to immunization with liposomal M2e influenza vaccine.

identifier:	1834430
description:	epitope description:MSLLTEVETPIRNEWGCRCNDSSD antigen name:Matrix protein 2 host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	21545821

study type:	b cell assays
subject species:	Influenza A virus

fullName:	Jill Adler-Moore Meilen Munoz Hana Kim Juan Romero Terrence Tumpey Hui Zeng Chris Petro William Ernst Suzie Kosina Gretchen Jimenez Gary Fujii

method:	in vivo assay

name:	Characterization of the murine Th2 response to immunization with liposomal M2e influenza vaccine.
description:	Liposomal epitope vaccination protected mice against H1N1(A/PR/8/34) challenge as shown by survival and weight loss studies. In vivo depletion of CD4+ T cells reduced survival percentage and exacerbated weight loss. The authors concluded that CD4+ cells were critical for full expression of the liposomal epitope vaccine's protective response, supporting stimulation of a Th2 response by the vaccine.

name:	iedb
homePage:	http://www.iedb.org

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