Intraneuronal APP, not free Abeta peptides in 3xTg-AD mice: implications for tau versus Abeta-mediated Alzheimer neurodegeneration.

Title:

Intraneuronal APP, not free Abeta peptides in 3xTg-AD mice: implications for tau versus Abeta-mediated Alzheimer neurodegeneration.

identifier:	1835651
description:	epitope description:LVFFAEDVGSNKGAIIGLMVGGVVIA antigen name:Amyloid beta A4 protein host organism:Mus musculus antibody name:4G8
aggregation:	instance of dataset
availability:	available
primaryPublications:	21613482

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Matthew J Winton Edward B Lee Eveline Sun Margaret M Wong Susan Leight Bin Zhang John Q Trojanowski Virginia M-Y Lee

method:	western blot

name:	Intraneuronal APP, not free Abeta peptides in 3xTg-AD mice: implications for tau versus Abeta-mediated Alzheimer neurodegeneration.
description:	The epitope-specific mAb recognized the antigen in cortical lysates from Tg2576, 3xTg-AD, and non-Tg mice. Significantly lower levels of APP transgene expression were detected in 3xTg-AD mice as compared to age-matched Tg2576 mice.

name:	iedb
homePage:	http://www.iedb.org

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