A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies.

Title:

A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies.

Dataset

identifier:	1835561
description:	epitope description:WNWFDITN antigen name:Envelope glycoprotein gp160 host organism:Homo sapiens antibody name:Z13e1
aggregation:	instance of dataset
availability:	available
primaryPublications:	19515770

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1016394
landingPage:	http://www.iedb.org/assay/1835561

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2009

Dimension

study type:	b cell assays
subject species:	Human immunodeficiency virus 1

Person

fullName:	Robert Pejchal Johannes S Gach Florence M Brunel Rosa M Cardoso Robyn L Stanfield Philip E Dawson Dennis R Burton Michael B Zwick Ian A Wilson

Data Type

method:	ELISA

Study

name:	A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies.
description:	The Fab bound the epitope by ELISA. The epitope was synthesized to contain KKKK sequence at its C-terminus to aid peptide solubility.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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