Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity.

Title:

Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity.

Dataset

identifier:	1835630
description:	epitope description:NNTRKSIHLGPGRAFYATGDIIG antigen name:Envelope glycoprotein gp160 host organism:Homo sapiens antibody name:Fab 2219
aggregation:	instance of dataset
availability:	available
primaryPublications:	16731948

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022125
landingPage:	http://www.iedb.org/assay/1835630

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2006

Dimension

study type:	b cell assays
subject species:	HIV-1 M:A

Person

fullName:	Robyn L Stanfield Miroslaw K Gorny Susan Zolla-Pazner Ian A Wilson

Data Type

method:	x-ray crystallography

Study

name:	Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity.
description:	Interaction between the Fab and the epitope was determined by X-ray crystallography.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.