Intraneuronal APP, not free Abeta peptides in 3xTg-AD mice: implications for tau versus Abeta-mediated Alzheimer neurodegeneration.

Title:

Intraneuronal APP, not free Abeta peptides in 3xTg-AD mice: implications for tau versus Abeta-mediated Alzheimer neurodegeneration.

identifier:	1835670
description:	epitope description:S202, T205 + PHOS(S202, T205) antigen name:Microtubule-associated protein (UniProt:I3L170) host organism:Mus musculus antibody name:AT8
aggregation:	instance of dataset
availability:	available
primaryPublications:	21613482

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Matthew J Winton Edward B Lee Eveline Sun Margaret M Wong Susan Leight Bin Zhang John Q Trojanowski Virginia M-Y Lee

method:	immunohistochemistry

name:	Intraneuronal APP, not free Abeta peptides in 3xTg-AD mice: implications for tau versus Abeta-mediated Alzheimer neurodegeneration.
description:	Immunohistochemistry was performed on cerebral cortex of 3xTg-AD and 3xTg-AD;BACE-/- mice (5-7 or 10-12 months old). A similar extent of tau immunoreactivity in the perikarya of cortical and hippocampal neurons of 5- to 7-month-old 3xTg-AD (Fig. 7A–C) and 3xTg-AD/BACE-/- mice was observed. Tau immunoreactivity increased in older 10- to 12-month-old 3xTg-AD. However, the absence of BACE protein and therefore free A beta peptides did not alter the distribution or intensity of tau pathology.

name:	iedb
homePage:	http://www.iedb.org

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