Structural basis of the cross-reactivity of genetically related human anti-HIV-1 mAbs: implications for design of V3-based immunogens.

Title:

Structural basis of the cross-reactivity of genetically related human anti-HIV-1 mAbs: implications for design of V3-based immunogens.

identifier:	1835377
description:	epitope description:KGVRIGPGQA antigen name:Envelope glycoprotein gp160 host organism:Homo sapiens antibody name:Fab 447-52D
aggregation:	instance of dataset
availability:	available
primaryPublications:	19913488

study type:	b cell assays
subject species:	HIV-1 M:A

fullName:	Valicia Burke Constance Williams Madhav Sukumaran Seung-Sup Kim Huiguang Li Xiao-Hong Wang Miroslaw K Gorny Susan Zolla-Pazner Xiang-Peng Kong

method:	x-ray crystallography

name:	Structural basis of the cross-reactivity of genetically related human anti-HIV-1 mAbs: implications for design of V3-based immunogens.
description:	The crystal structure of the epitope-specific mAb bound to an epitope-containing peptide was determined. There are two Fab/V3(W2R) peptide complexes in the crystallographic asymmetric unit. The epitope sequence was observed to have strong electron densities.

name:	iedb
homePage:	http://www.iedb.org

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