Cross-reactive binding of cyclic peptides to an anti-TGFalpha antibody Fab fragment: an X-ray structural and thermodynamic analysis.

Title:

Cross-reactive binding of cyclic peptides to an anti-TGFalpha antibody Fab fragment: an X-ray structural and thermodynamic analysis.

identifier:	1835774
description:	epitope description:VVSHFND antigen name:Protransforming growth factor alpha host organism:Mus musculus antibody name:tAb2
aggregation:	instance of dataset
availability:	available
primaryPublications:	11718562

study type:	b cell assays
subject species:	Homo sapiens

fullName:	M Hahn D Winkler K Welfle R Misselwitz H Welfle H Wessner G Zahn C Scholz M Seifert R Harkins J Schneider-Mergener W Hö hne

method:	calorimetry

name:	Cross-reactive binding of cyclic peptides to an anti-TGFalpha antibody Fab fragment: an X-ray structural and thermodynamic analysis.
description:	The binding of the epitope-specific tAb2 antibody and Fab fragment to the cyclized hcc-pep1 peptide was determined by isothermal calorimetry at 10, 25, and 35ºC. The value for the antibody in phosphate buffer at 25ºC is shown. The peptide was cyclized by disulfide bond formation between the N-terminal and C-terminal cysteine residues.

name:	iedb
homePage:	http://www.iedb.org

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