Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step.

Title:

Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step.

Dataset

identifier:	1839030
description:	epitope description:W529, G530 antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:H77.36
aggregation:	instance of dataset
availability:	available
primaryPublications:	21543495

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022230
landingPage:	http://www.iedb.org/assay/1839030

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2011

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus (isolate H77)

Person

fullName:	Michelle C Sabo Vincent C Luca Jannick Prentoe Sharon E Hopcraft Keril J Blight Minkyung Yi Stanley M Lemon Jonathan K Ball Jens Bukh Matthew J Evans Daved H Fremont Michael S Diamond

Data Type

method:	flow cytometry

Study

name:	Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step.
description:	The epitope-specific mAb bound to recombinant E2 protein. The residue(s) comprising the epitope were determined by loss of binding to mutated E2 proteins displayed in a yeast-display library. Pre- and postattachment assays revealed that the mAb bound after the virus attached to host cells.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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