Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1840782 |
| description: |
epitope description:I573, K574, Q577, R633, N636, S640, H643, H564, Q567, L568, T569, W571, G572, K574, Q575, L576, A578, R579
antigen name:Envelope glycoprotein gp160
host organism:Homo sapiens
antibody name:D5
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
16862157 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1022126 |
| landingPage: |
http://www.iedb.org/assay/1840782 |
| type: |
Literature
|
| publicationVenue: |
Nat Struct Mol Biol
|
| dates: |
2006
|
| study type: | b cell assays |
| subject species: | HIV-1 M:B_HXB2R |
| fullName: |
Micah A Luftig
Marco Mattu
Paolo Di Giovine
Romas Geleziunas
Renee Hrin
Gaetano Barbato
Elisabetta Bianchi
Michael D Miller
Antonello Pessi
Andrea Carfí
|
| method: |
x-ray crystallography
|
| name: |
Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody.
|
| description: |
The epitope residues were calculated from the PDB structure (2CMR) as the antigen residues at 4 Å
distance from the antibody.
The epitope of scFv D5 on mimic of gp41 pre-hairpin intermediate 5-helix was determined from the crystal structure. The peptide sequence is a construct where three regions each equivalent to aa 543-582 of gp41 are interspersed by two different regions (each equivalent to aa 625-662). Linkers GGSGG and GSSGG join the regions and alternate starting with GGSGG. A methionine initiates and a tail contains GGHHHHHHG.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
