Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1.

Title:

Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1.

identifier:	1842128
description:	epitope description:E43, N44, I45, E46, G47, N48, G49, G50, P51, G52, T53, R71, D73, H77, I87, K98 antigen name:Bet v 1 host organism:Mus musculus BALB/c antibody name:mAb BV16
aggregation:	instance of dataset
availability:	available
primaryPublications:	21454600

study type:	b cell assays
subject species:	Betula pendula

fullName:	Jens Holm Mercedes Ferreras Henrik Ipsen Peter A Wü rtzen Michael Gajhede Jø rgen N Larsen Kaare Lund Michael D Spangfort

method:	surface plasmon resonance (SPR)

name:	Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1.
description:	The epitope-specific mAb bound Bet v 1 and a recombinant antigen in which the epitope residues were grafted into the surface of apple major allergen Mal d1. Mutations of the epitopic residues reduced binding.

name:	iedb
homePage:	http://www.iedb.org

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